Methotrexate is a treatment for Rheumatoid Arthritis. The standard way forward when you are diagnosed with RA is that your Rheumatologist will run you through a set of medications
- Hydroxychloroquine
- Methotrexate 15mg orally
- Methotrexate injections
- Humera
- …
I’ve currently progressed to the Methotrexate Injections

The manufacturer has a website with a video of how to use it : https://www.methofill.co.uk/patient
It was almost painless to use, much less painful that the sumatriptan injectors for migraines that I used to use. I did feel odd afterwards and was glad that I was in bed, the next day, Tuesday was nauseous and Wednesday was the usual migraine and generalised pain ( 4-6/10 ). Better by Friday I hope.
This is a 15mg injection, this should start to have an impact on my inflammatory markers ( ESR and CRP ) soon, but I have to keep an eye on liver breakdown protein to make sure that my liver does not take too much damage ( it can regenerate ? ). My Rheumatologist will increase the methotrexate injection amount as necessary. Blood tests every 2 weeks.